Malignant Jaundice Treatment

• January 22, 2023
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Malignant Jaundice Treatment in Vasundara; Malignant obstructive jaundice can be caused by cholangiocarcinoma, gallbladder carcinoma, metastatic lymphadenopathy and pancreatic carcinoma. Most of the cases are inoperable at diagnosis and are treated with palliative intent. Relieving the obstruction and normalizing the serum bilirubin level is usually the first step in this endeavor. Cholangiopancreatography and stenting is the preferred method for relieving the obstruction. When obstruction is localized in the intrahepatic radicals and ERCP is not possible, percutaneous transhepatic cholangiography and biliary drainage is the only feasible option. Biliary decompression and stenting is effective in relieving the jaundice, however, high rates of stent occlusion has been reported. Cholangiocarcinoma and gallbladder carcinoma have a tendency to invade bile ducts, hence stent occlusion due to tumor ingrowth or overgrowth is inevitably high. Thus, in addition to stenting, an effective therapy is needed which can provide high palliation in form of prolong stent patency. External beam radiotherapy has been attempted, but major deterrents to improve results with EBRT alone are proximity of adjoining critical normal structures, high doses required to effectively irradiate these neoplasms, lack of clear localization of lesion and respiratory movements.

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